#The7thLiChuangDianJiang#Medical Electronics IVD Fluorescence Detection Module

Note: * is a required field,
please fill it in during the registration stage↓
 
* 1.
Please enter the content of the project function introduction...
The main purpose is to develop an IVD fluorescence test module, continuously improve the performance and reduce the cost, and hope to learn and communicate with the industry leaders
. Note: The topic is not limited, it can be a solution to a problem in life/work, a solution designed for a certain group of people/scene, a graduation project/course design/DIY project/purely cool project, etc. Mainly talk about what problem you solved by what means.
 
*2. The project attribute
 
is original and first public
* 3.
Please enter the content of the open source agreement...
CERN Open Hardware License
Note: Altruism is self-interest, please read the following content carefully.
Embrace open source and give unlimited value to the project. It is recommended that more than 80% of the core functions of the project be open source;
if a part of the functions is irreplaceable and the project cannot solve the corresponding problem after deleting it, then the functions implemented by this part are the core functions of the project; for example, if an electronic load is designed and a host computer software is designed to monitor power changes, the electronic load is the core function and the host computer software is an auxiliary function; for example, an isolated 485 module is used in the electronic load to communicate with the host computer, then the communication function implemented by this 485 module is an auxiliary function;
the project should choose an open source protocol that suits it. If the project quotes other open source projects, the source should be indicated and the original author's open source protocol regulations should be followed; original projects are recommended to use the GPL3.0 open source protocol;
functions implemented by directly quoting the original circuit or original code of the open source project cannot be used as the core functions of your own project, and functions directly implemented using general modules on the market cannot be used as the core functions of your own project.
 
Please fill in the form during the competition↓
 
*4. Please enter the content for the hardware part
...
 
I have come across this type of IVD detection optical module at work, but the performance has always been unsatisfactory. After leaving the job, I have always wanted to make such a module for testing. I have had this idea for several years. During this process, I occasionally participated in several CMEFs and saw similar modules. The communication and understanding were basically the T-shaped structure shown in the figure below. Finally, I decided to use this solution. Several versions were made in succession, and the solution was continuously optimized and refined during this process. The picture is from the in vitro diagnostic industry technology textbook.
During the design process, it is mainly composed of optical path, hardware, and structure. Among them, the optical path is the most difficult. First of all, the optical knowledge remains at the high school level, and I have not been exposed to optics in college. I can understand the pictures, but I have no idea where to start when it comes to designing. And the worst thing is that the lenses are not cheap, really not cheap. You may not have the money to customize them even if you are willing to design. I used to customize a filter for 1500 10 pieces, which was really unaffordable. As for convex lenses, I didn't even ask about them. After all, I couldn't design anything myself. So the optics is basically to find ready-made or similar processes. It's a long process, so I won't describe it. In short, a friend helped me a lot in this part and solved some money and design problems. In a word, big companies are good.
After the optical path was gradually finalized, since I was working on hardware, there was basically no problem with the hardware. The remaining part was the structure. I started to talk about this part with my colleagues in my spare time. I felt that sometimes it was difficult for them to understand or comprehend the core of my design. I was also embarrassed to ask my colleagues for free, so I learned soildworks by myself. If I didn’t understand, I would ask my colleagues. After a month or so, I basically got the hang of it. Now, as long as it is not too complicated or various curved structures, I can handle it. After I learned how to do the structure, I started to design. At that time, 3D printing was still the kind of spinning mode, and the accuracy was completely unbearable. There was no other way but CNC proofing. Compared with hardware, structural CNC proofing is also very expensive. I made 3 modules and charged 600, which is the structure below. When I talked about it with my colleagues, he said it was not expensive..., I won’t say anything about hardware proofing. Jiali Chuang’s proofing is really good. (I looked at the circuit board above and it was still in November 2019. Time flies so fast)
   
After designing this fluorescent module, I felt good about myself. After all, it is really delicate and compact. The AD value of static test is still very stable. But the module was not ideal during assembly, mainly because glue was put into it during assembly, and basically all the lenses were scrapped. There was no way to install another one, but when I wanted to test the reagent card, it got stuck again. At this time, I needed to move the slide again, and then some things at home came to a standstill.
The new adapter appeared in Jiali Chuang to provide 3D proofing. It just opened and provided free 3D proofing. This wool must be taken, so I hurriedly designed the motion platform. Because I rushed to finish the design before the deadline, I bought the slide directly. After the design, I made the proof directly. The material I chose was still relatively expensive. As shown in the figure below, a base plate with a thickness of 10mm is used to place the slide and circuit board, which is very luxurious. There is also a fixed fluorescent module. Now it is estimated that this proofing will cost more than 200 yuan. I have to say that Jiali Chuang's proofing is really good.
 
This set is considered to be completed, but in summary, there is only one problem. The cost is too high. The main reason is that the CNC of the fluorescent module is not realistic, expensive and difficult to install. The slide is also more than 100 yuan, which feels expensive. Later, I reduced the cost from these two structures. I also made several summaries on the slide, but I still think it is practical to buy a slide. Other solutions are either too light or too heavy. In general, the motor selection is difficult. The best one should be the permanent magnet stepper motor with a diameter of 25-35mm, but it is indeed a bit expensive. If you choose a permanent magnet, it is better to use a ready-made module. The following are several slides I designed in this process. I
will not toss about the slide, but start to toss about the fluorescent module. After all, CNC is expensive and difficult to install, so let's use 3D printing. The core structure of the fluorescent module has basically not changed. The biggest difference is to adapt to various existing lenses and circuit boards. These are all determined, but the design is not very difficult. In this process, two models are also designed. The core has not changed. The main thing is that one has only an ADC chip, and the other is based on the ADC chip with an MCU, which may be more convenient to use. See the figure below.
 
This is the final work of this open source, which can be regarded as an explanation to myself. After a long time of twists and turns, I finally made a product that I am quite satisfied with. The overall cost of the structure has been reduced a lot, but the tragedy is that the cost of hardware has increased in the past two years and it has saved more than the structure. I chose AD7689, which is very expensive to buy now. This chip has been repeatedly desoldered and disassembled many times, and it has been iterated and disassembled. I will not toss it this time, and optimize it later. This time, the open source is open here to start a discussion. The hardware is not a big problem for hardware people.
For this open source, a small control board was specially made. The control board is mainly used to transmit signals and control the rotation of the motor. This part is also open source. Everyone can make do with it.
The following is the data of the IVD fluorescence module test gradient card.
Conditions: There are gradient cards with 1-7 concentrations (opened in 2019) (4 concentrations have been lost)
Test results: Each gradient is tested 3 groups repeatedly, the left curve is a curve with 3 low gradients; the right curve is a curve with 6 gradients. In general, the consistency of high gradient is very good, and the curves basically overlap. There is a certain degree of distinction in low concentration, but it is not very good. It may also be related to my card, but if you look closely, you can still see that there are 3 sets.
The original data will be packaged for interested friends to verify and
   summarize. When you want to make something, you will keep trying. The best result is the satisfaction when the real thing appears in front of you. Although the entire time span is very large, every step I have taken is a preparation. I also hope to continue to improve this fluorescence detection module with everyone. The fluorescence module is still widely used in the IVD field, and I hope it can become a mature product as soon as possible.
 
 
 
Note: It is recommended to use Jiali Chuang EDA. If you choose other EDA tools, please upload the schematic diagram in PDF format, the PCB drawing in PDF format, and the PCB file in Gerber format in the attachment. Here you can explain in detail the implementation principle and mechanism of your project, precautions, debugging methods, testing methods, etc. It is recommended to introduce your ideas to others in the form of pictures and texts.
 
*5. Software part
 
 
Note: If your project involves software development, please upload the corresponding engineering source code in the attachment. Here you can explain in detail your software flow chart, functional module block diagram, explanation or popular science of related algorithms, source code structure, construction and configuration of the compilation environment, source code compilation method, program burning method, etc. It is recommended to introduce your ideas to others in the form of pictures and texts. Source
code is attached
*6. BOM list,
please enter the content...
 
Note: BOM list involved in the project. Please upload a screenshot of the BOM in this position. Please upload the list details in PDF format to the attachment. It is recommended to include model, brand, name, package, procurement channel, purpose, etc. The specific content and form should be based on the clear expression of the project composition.
BOM is attached
*7. Competition LOGO verification
  Click zip to download the competition logo! (Competition logo).zip
 
* 8. Demonstrate your project and record it into a video to upload.
Video requirements: Please shoot horizontally, with a resolution of no less than 1280×720, in Mp4/Mov format, and a single video size limited to 100M;
Video title: Lichuang Electric Competition: {Project Name}-{Video Module Name}; For example, Lichuang Electric Competition: "Autonomous Driving"-Team Introduction.
 
More details: https://diy.szlcsc.com/posts/d76d9cb41705430e9a54e7a5feed07a5